Companion Studies

Cardiotoxicity in Breast Cancer Patients Treated with Proton or Photon Radiotherapy

The overall objectives of this NIH-funded ancillary study (NCT04361240) to the RadComp clinical trial are to determine how early subclinical measures of cardiovascular injury and dysfunction differ according to radiation therapy type (proton vs photon) and which radiation therapy dose-volume parameters influence cardiovascular biomarkers.

Principal Investigator: Dr. Bonnie Ky, MD, MSCE and Dr. Justin Bekelman, MD

The Differential Impact of Proton Beam Irradiation Versus Conventional Radiation on Organs-at-risk in Stage II-III Breast Cancer Patients

The objective of the study is to serve as a correlative study (NCT03270072) to the RadComp trial, a randomized phase III study of stage II and III breast cancer patients treated with either conventional photon radiation or proton beam radiation.

Principal Investigator: Rachel Jimenez, MD